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KMID : 1149120230200010027
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Journal of the Korean Society for Psoriasis
2023 Volume.20 No. 1 p.27 ~ p.30
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Two Cases of Childhood Generalized Pustular Psoriasis Successfully Treated with Cyclosporine
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Sung Jae-Young
Kim Chang-Yong
Cho Young-Ah
Yu Da-Ae
Lee Yang-Won
Choe Yong-Beom
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Abstract
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Generalized pustular psoriasis (GPP) is a rare, life-threatening form of psoriasis characterized by widespread sterile pustules on erythematous skin and is even rarely found in children. Prompt diagnosis and treatment are necessary as GPP flare can be life-threatening. Due to its rarity, there are currently no treatment guidelines for childhood GPP in Korea.
In this report, we present two cases of 8-year-old boys with childhood GPP who were successfully treated with cyclosporine. Both patients had extensive erythema with papulopustular lesions on the trunk and extremities. One patient had been treated with systemic corticosteroid in another clinic and showed resolution but eventually showed recurrence and flare. Another patient had intermittently tried low dose oral acitretin and topical steroid treatment in another clinic. We started treatment with cyclosporine for periods of 15 weeks and 10 weeks respectively, until their lesions showed clearance. Our cases suggest that cyclosporine is a safe and effective treatment option for acute GPP in children.
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KEYWORD
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Childhood generalized pustular psoriasis, Cyclosporine
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